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  1. #1
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    How accurate is the harmony test for sex determination?

    Has anyone been told the sex wrong?

    Has anyone been told there baby has not downs etc but then born with a trisomy?

    Thanks
    84 March 2012

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    I have no idea but I am interested to know. I am having my 12 week ultrasound in London and was wanting to do this test depending on what clinic they send me to! Not sure what the 12 week screening entails in London and if it's different from the US but if I can find out at 12 weeks the gender I will be happy lol

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    They send the results back to the us as there is no lab in the uk yet. So it takes 2-3 weeks. You can have it done on Harley street but only a few clinics in the uk offer it.

    I have emailed the clinic and asked them if they don't get back I will phone them on Friday and update here
    84 March 2012

  4. #4
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    A girl on here was told her baby could have an anomaly but then it turned out the baby was fine. I do think it's a very accurate test and certainly safer than any of the alternatives.
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  5. #5
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    The harmony test is over 99% accurate on gender determination. It also only has a less than .1% false positive rate. Which basically means it is very hard to get a positive but be carrying a healthy baby. Which is good for the "lets not freak people out for no reason" clause. Lol.

    And as far as how accurate it is for detecting the trisomies, it's highest accuracy is T21, very closely followed by T18. Both of those are 99% range (in the same study of 230 mothers, one T21 was missed, two T18 were missed...which is basically less than .5% missed diagnosis). T13 was about 8/10 detected. Although given the severity of T13, I imagine the sample study was smaller.

    So for your question...you would have less than .1% chance of being told no Down's syndrome and then having a child with Down's syndrome.
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    Greesemonkey, presume you are having this done privately as Harmony certainly won't be done on the NHS. 12 week scan in UK entrails bloods and a scan which will show fetal heart action, crown rump length and NT as well as looking at skull, brain, spine heart, stomach and the upper and lower extremeties for any potential abnormalities. You basically also get a background risk, dependent on your age and then an adjusted risk based on your blood results for these. Interestingly, some clinics in London that do Harmony won't tell you gender though, just chromosomal abnormality risk eg Fetal Medical Centre, whereas others will, so best to double check if you want to know gender. I know Polli had the Harmony Test at the Birth Centre in Harley Street where they do tell you gender. Good luck xx

  7. #7
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    I think GT77 did the MaterniT21 test. It came back XXX but baby is XX.
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  8. #8
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    I think they are basically the same test, but one gives you a y/n answer and the other gives odds.
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  9. #9
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    I disagree. For anyone who is told down 21 is usually correct but not for 18 or 13 and sometimes a boy comes up for gender instead of an. Xx. Also, I heard its wrong for 18 and 13 and xxx and xxy 1 out of 10 tests. I know for a fact my hcg is off the charts I can't help but think that they thought if I'm not two in there how come my hcg is so high where is extra xx coming from. We don't know how these tests are done and how. If u r 35 and above then get a cvs or amnio .


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  10. #10
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    Disagree with what part???

    The fact is that these are pretty darn new tests and we probably just can't say about levels of false neg and false pos tests. They're probably going to happen in both directions

    That's not how HCG levels and XX vs XXX work. They literally were counting chromosomes in the fetal blood in your blood****** and miscounted something. Human error.

    I BEG you guys not to go rushing in to get a CVS or amnio if they are not needed. These tests may not be perfect but at the least they can tell you if you even need a more invasive test. There are people on this site who lost perfectly healthy babies because they were pressured into having these invasive tests done solely because they were over 35. I would take a false positive result on a blood test any day of the week rather than lose a healthy baby.
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