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Thread: PICSI

  1. #1
    Dream Vet

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    PICSI

    Hi Carole,

    During our last IVF cycle, the sample used had a count of 3 mil/ml, motility 27%, progression 1-2/4 and 98% abnormal forms. We got 14 eggs, 6 fertllised using ICSI and only 2 embryos were left and available for transfer on day 3. 1x8 cell grade A and 1x6 cell grade B.

    Does a poor SA often lead to poor fertilisation rates, and do you think PICSI helps to overcome this? Do you see a significant difference in fertilisation rates and embryo quality when PICSI is used?

    Thank you
    Mummy to and twin

    Cycle 1 HRC June 2014. 25 eggs, 19 mature, 13 fertilised, 10 to day 5 testing. 6 normals (2XX and 4XY). Transferred 1XX HB AB - BFP

  2. #2
    Dreamer

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    Quote Originally Posted by kayos View Post
    Hi Carole,

    During our last IVF cycle, the sample used had a count of 3 mil/ml, motility 27%, progression 1-2/4 and 98% abnormal forms. We got 14 eggs, 6 fertllised using ICSI and only 2 embryos were left and available for transfer on day 3. 1x8 cell grade A and 1x6 cell grade B.

    Does a poor SA often lead to poor fertilisation rates, and do you think PICSI helps to overcome this? Do you see a significant difference in fertilisation rates and embryo quality when PICSI is used?

    Thank you
    Hi there,

    The high abnormally-shaped forms is probably the main culprit in poor fertilization and poor embryo development that you describe. PICSI is useful to pick the most mature IVF ready sperm and some research suggests it can be helpful--but only if you have a lot of sperm to choose from. If the lab is struggling to find normal shaped sperm visually, then PICSI may not be that beneficial. I would still feel hopeful about your transfer of day 3 -8cell and 6 cell embryos. Good Luck!!! Carole

  3. #3
    Dream Vet

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    Carole, do you find PICSI is helpful with a normal semen analysis? We had 100% fertilization with ICSI, but had a Hugh number of sperm chromosome abnormalities on the sperm side. Does PICSI aide in selecting sperm that are euploid?
    DW (33), DH (35) to ODS (11) and YDS (6) and (2016). Hoped to add a little in 2014/2015, but it appears it is going to take way longer than expected.

    Cycle 1 - May 2013 - HRC - retrieval - Feb 2014 FET Planned Transfer - early blast resulted in a chemical (Chemical #1).
    Cycle 2 - May 2014 - HRC - No Normal XX embryos - No Transfer
    Cycle 3 - October 2014 - HRC - Retrieval and Unplanned FET in December 2014 - Normal XX resulted in another chemical (Chemical #2).

    January 2015 Immune Testing with Dr Braverman - He suspects mild endometriosis is my issue and wants me to have a lap.
    April 2015 lap surgery scheduled with renowned endometriosis surgeon. Stage 2 endometriosis found and excised!

    FET #3 - June 2015 - HRC - On Dr Braverman Immune Treatment (Lovenox, Prednisone, Intralipids, and Femara) My last xx embryo didn't survive the thaw (transferred backup donor embryo) - Chemical #3

    June 2015 - Sign up with adoption agencies as current plan (IVF does not seem to work for me).

    July 2015 - Receive 2 beautiful xx donor embryos! Decided to hire a proven surrogate to transfer to so I can end my quest for baby girl.

    September 2015 - First Natural Attempt without protection in 6 years = BFP 7dpo Beta 13 dpo 221, Beta 15 dpo 653, Seen at 6 and 8 Weeks! Panorama Test reveals bubs is another so transfer with surrogate/adoption is still on! Ask Braverman why this is happening and now he says we must have "gender dreamer issue" and not immune issues?!

    Received calls about baby girls for Adoption in November 2015, May 2016, and August 2016 - All had to turn down because of planned surrogacy transfers.

    January 2016 - FET #1 with proven surrogate - BFP 4dpt, Beta 12dpt 601, Beta 14 dpt 1,342, Beta 18dpt 734... CHEMICAL #4

    May 2016 - Baby Boy arrives healthy at 39 weeks (planned c section) - 8.5 lbs! I love love love this baby boy. He is such a blessing and a rainbow to me!

    July 2016 - FET #2 with proven surrogate and last donor embryo - BFP 3.5dpt! Beta 11dpt 374, Beta 13dpt 828, Beta 15dpt 1,689, Beta 18dpt 4,925! Seen at 6 weeks, 8 weeks, 10 weeks, and 12 weeks. Went for Gender Scan at 16 weeks and it shows baby passed away at 15 weeks.

    I JUST DON'T GET IT. HOW DOES THIS HAPPEN?? SO SAD.

    Moving onto Adoption - I need to believe in a Real Live Baby and not a theory of a baby!

    UPDATE!! We have our new daughter through adoption March 2017!! We are in love and our family is complete!!

  4. #4
    Dream Vet

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    Hi Carole,

    Thanks so much for your response, our IVF worked, those 2 embryos are running round my living room right now :-)

    I'm just wondering how we might improve things for our upcoming cycle, my husband has been following a much healthier lifestyle and an SA yesterday came back at 34 mil/ml, up from 3mil/ml, motility 13 % grade a (rapid), 13% grade b (sluggish), 5% non progressive and 69% immotile. Morphology is now 4% normal and 1% borderline. So it seems that the count at least has improved. Would this improvement make it easier for the lab to pick out the better sperm?

    Many Thanks, Kay
    Mummy to and twin

    Cycle 1 HRC June 2014. 25 eggs, 19 mature, 13 fertilised, 10 to day 5 testing. 6 normals (2XX and 4XY). Transferred 1XX HB AB - BFP

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