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  1. #1
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    Free β-hCG and PAPP-A levels and baby's gender

    These studies are showing the link between free β-hCG and PAPP-A levels in mothers blood and baby's gender. Values tend to be higher in women pregnant with girls.
    Average ( desired) value is 1 MoM.

    Also NT ( nuchal translucency) and AFP can be expressed in MoMs.

    If you're pregnant with a boy, those values tend to be a bit higher, but close to 1 if it's a normal, healthy pregnancy ( otherwise it could be an indicator for chromosomal issues). If you're carrying a girl, values tend to be a bit lower then 1 ( but close to 1 for the same reasons).

    Those hormones are done from the blood ( 'double test') usually during the first trimester and they are interpreted with ultrasound pictures in order to show the probability that the baby might suffer chromosomal problems ( mostly trisomy 21, 18,15).

    My ob/gyn orders double test only if the future mommy is older then 35 and/or u/s is indicating something might be wrong.

    These studies were like the punch in the face, burying my last hope for a baby boy ( hey, I've almost convinced myself this baby can turn into a boy )

    Here are the studies: The impact of fetal gender on first trimester nuchal translucency and maternal serum free β-hCG and PAPP-A MoM in normal and trisomy 21 pregnancies - Cowans - 2009 - Prenatal Diagnosis - Wiley Online Library ( The impact of fetal gender on first trimester nuchal translucency and maternal serum free β-hCG and PAPP-A MoM in normal and trisomy 21 pregnancies)
    Gender impact on first trimester markers in Down syndrome screening - Larsen - 2002 - Prenatal Diagnosis - Wiley Online Library

    There are more studies on this subject and they are all showing the same, unfortunately

    Here are my double test results at 12 weeks 6 days:

    free beta hCG: 1.21 MoM
    PAPP-A: 0.96MoM
    NT: 0.96 MoM

    Girl, eh?
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  2. #2
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    Here's the link to the study about NT values The effect of fetal gender on nuchal translucency at 10–14 weeks of gestation - Lam - 2001 - Prenatal Diagnosis - Wiley Online Library

    NT for female fetuses was 0.98 MoM compared to 1.o3 MoM for male fetuses.
    Last edited by Zivic-Bubac; April 22nd, 2012 at 04:59 PM.
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  3. #3
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    This is so unbelievebly exciting!!! I've found another study for the first trimester with actual values for free beta hCG and PAPP-A
    http://www.fetalmedicine.com/fmf/2009_11.pdf

    Free β-hCG 0.95 MoM for boys
    1.09 MoM for girls

    PAPP-A 0.96 MoM for boys
    1.02 MoM for girls


    Free β-hCG is 14.74% higher if the fetus is a girl ( considered significantly higher) and PAPP-a is 6.25% higher in girls.

    Of to find AFP values for the 2nd trimester!
    Last edited by Zivic-Bubac; April 23rd, 2012 at 10:36 AM.
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    And yes, there is a link between AFP levels ( α - fetoprotein) and baby's gender!

    Reproductive factors and extreme l... [Acta Obstet Gynecol Scand. 2004] - PubMed - NCBI
    Women who gave birth to a girl had AFP levels that were 5% lower than those of women who had a boy.

    2nd-trimester maternal serum human chorionic gonadotropin and alpha-fetoprotein levels in male and female fetuses with Down syndrome.

    I'll try to find some numbers.
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  5. #5
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    Cut-off for AFP is 2-2.5 MoM

    Role of fetal sex in amniotic fluid alphafetoprotein screening - Knippel - 2002 - Prenatal Diagnosis - Wiley Online Library
    This is the conclusion from this study: " Adjusting the cut-off MoM to 2.5 for male and to 2.0 for female fetuses halves the false positive rate from 3.4 to 1.7% without affecting the detection rate of 95%."
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  6. Thanks Nell_ thanked for this post
  7. #6
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    I can't believe no one else finds this interesting?
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  8. #7
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    Hey Z I know nothing about all this, sorry!!
    Fathers Day baby!


    Busy Mummy of 5 now working from home: www.oz.scentsy.com.au

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    Quote Originally Posted by TTC5 View Post
    Hey Z I know nothing about all this, sorry!!
    Oh, don't be sweeti!
    I was so thrilled when I've found it. I'd be even more so if I was in the boy range

    If we go for no.4 my ob/gyn will have me do double and triple tests just like that bcos I'm going to be closer to grandma age lol! So I'll know very, very soon that I ( most likely) failed again.
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  10. #9
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    I have read this before but I only had one NT scan and that was with DS. I never got any of my levels from the 16 week scan.
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  12. #10
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    All I know is, my AFP tests were very positive for DD2 (1:19) and she was (obviously) a girl, and has no downs syndrome. The same test with my son was positive too, but just barely--1:240. He was healthy as well. This time around I got a result of 1:200, not sure if it was the same exact test--I think they said it was the quad screen? Not sure. DD1 all I know is I "passed" but not sure what the result was. I was only 30 then, so that may have helped.

    Not sure of the exact levels of things and don't know what MoM is.
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