Thread: Natera Update
-
February 19th, 2013, 08:55 PM #1Moderator
- Join Date
- Dec 2010
- Location
- Newport Beach, California
- Posts
- 441
- Post Thanks / Like
- Blog Entries
- 12
- Downloads
- 0
- Uploads
- 0
Natera Update
Hello Everyone. I am sad to report that Natera will no longer be doing PGD for fresh transfers for the time being. This will be in effect 3/1/13 for most centers and 3/15/13 for a few special cases.
Natera will continue to offer PGD for day 5 all freeze specimens.
This change is being done for purely business reasons. Natera and myself still believe that we have the best PGD product on the market.
Natera has made a decision to focus the manpower that they have on the new Panorama test for the immediate future. As some of you are aware, Natera has launched Panorama, a non-invasive pre-natal diagnostic test that allows us to determine whether the child the patient is carrying is has one of the major aneuploidy syndromes and also whether it is a boy or girl (as well as paternity). Quite simply, the response to Panorama has been overwhelming and Natera has had to make the a decision use its available manpower to address this demand. In taking the fresh PGD testing off-line, Natera will be able to focus on servicing Panorama and a likely IPO over the year 2013. Natera remains committed to PGD and when fresh Natera PGD is relaunched, hopefully in 2014/15, we will be using sequencing technology along with our proprietary infomatics. This will allow very rapid turn around times and easily accommodate day 5 biopsies with fresh day 6 transfers or day 3 biopsies with day 5 transfers. I will be personally exploring the question as to whether we improve pregnancy rates using Natera and all freeze or aCGH with a day 6 transfer. This remains an open question and I intend to accumulate data on this matter and present it to the public as soon as I have sufficient data to present.
I will remain Laboratory Director for Natera for the immediate future until a suitable replacement can be found and we can transition to the new Director. The responsibilities of being Laboratory Director of what is rapidly becoming a very large company require more attention than I can manage and still practice medicine. I will remain Laboratory Director of the PGD division after this transition has been completed.
As for my practice, I will continue to offer Natera Day 5 biopsy on ‘all freeze’ cases but will be forced to transition to day 5/day 6 aCGH for all fresh cases. I am working with an aCGH laboratory to create a hybrid test that will improve accuracy with the Y chromosome and other small chromosomes. For cases currently in process at my center, we will continue to use the Natera day 3 with day 5 transfer for all cases biopsied on or before 3/15/13. All cases beyond that will be aCGH day 5 biopsy and day 6 transfer.Daniel A. Potter, MD
Medical Director, HRC Fertility Newport Beach, California
Laboratory Director, Natera (formerly Gene Security Network)
http://www.amazon.com/What-When-You-...keywords=hanin
http://www.danielapottermd.com
@ivfgenderselect
-
February 19th, 2013, 09:32 PM #2IVF Advice Coach
- Join Date
- Dec 2010
- Location
- The Internet
- Posts
- 24,567
- Post Thanks / Like
- Blog Entries
- 6
- Downloads
- 0
- Uploads
- 0
Thank you for posting.
I have seen Dr Sher's blog and he has posted about aCGH day 5 still being aCGH and not mCGH and the "accuracy" is the same as day 3, which we have seen opposites from so how can we be sure that day 5 aCGH is okay for GS? Is there any way to know for sure that it will not miss the Y chromosome?
I do hope that aCGH day 5/fresh 6 can work and of course be 100% accurate minus human error because for those that travel long distances, this is difficult to take to say the least.
I hope you are able to make a day 5 test and day 6 transfer work for them somehow.Mom to
and my IVF/PGD
It's better to look back on life and say: "I can't believe I did that" than to look back and say "I wish I did that".
New to IVF/PGD for Family Balancing? Read this- Understanding IVF/PGD- a HT Guide for those New to the IVF/PGD Process
Need a Natural Swaying Plan? Naturally sway for a boy or a girl- Personalized Swaying Plans
Become a Dream Member to access the private forums
-
February 23rd, 2013, 06:26 PM #3
I have also read that Natera's fees for a day 5 biopsy with a "freeze all" are lower than a day 3 biopsy with a day 5 fresh transfer. Will HRC consider lowering this cost to compensate for the added FET cycle cost?
Me: 31 DH: 29 and our family: 2005 2011 2013 2016
DOR at 0.15 AMH, AFC 8, FSH 8.1. Three fresh cycles and two donor embryo FET's we finally got our DD four years later. She completes us in a way I had only dreamed of.
-
March 9th, 2013, 09:10 AM #4
Hi nuthinbutpink,
I am hoping you can help me wrap my head around what this means for those of us travelling from overseas.
Based on my research around this site it would appear that best chances of success then going forward would be to do a FET with day 5 Natera.
Obviously that will mean 2 trips to the US (assuming you get at least one embryo to freeze). Question then becomes - how long would you need to stay for each visit?
On first visit I presume you could leave US as soon as egg retrieval was done and just receive your results by phone/email? So how many days in US before egg retrieval? And then return on second trip just for FET. How many days stay would that require?
2 trips will be more expensive but potentially more manageable in terms of being away from the kids for 2 shorter periods of time and reduces time DH has to be away from work.
Would really appreciate your thoughts or indeed anyone else's on this,
thanks
-
April 29th, 2013, 08:19 AM #5
hi, i am really new to all this and am wondering, in order to keep it relatively non invasive, would it be possible to use Microsort & Panorama in order to select gender and detect genetic anomalies? how accurate would the results be?
-
April 29th, 2013, 03:23 PM #6
I'm not Dr.Potter, but Microsort is long gone from the US, they don't do it anymore. I have never heard of Panorama, it must be some European test, they have different ones here.
-
April 29th, 2013, 03:51 PM #7IVF Advice Coach
- Join Date
- Dec 2010
- Location
- The Internet
- Posts
- 24,567
- Post Thanks / Like
- Blog Entries
- 6
- Downloads
- 0
- Uploads
- 0
Panorama is a blood test done on the mother after you are pregnant. The only way to verify gender prior to implantation is to biopsy the embryo. You have to get material from the embryo itself in order to verify gender outside of the womb prior to implantation.
Microsort is available in Mexico but not the US. There's really no such thing as non-invasive if you want a guarantee. You can do IVF and MS only but you still need IVF.Mom to
and my IVF/PGD
It's better to look back on life and say: "I can't believe I did that" than to look back and say "I wish I did that".
New to IVF/PGD for Family Balancing? Read this- Understanding IVF/PGD- a HT Guide for those New to the IVF/PGD Process
Need a Natural Swaying Plan? Naturally sway for a boy or a girl- Personalized Swaying Plans
Become a Dream Member to access the private forums
-
April 29th, 2013, 03:52 PM #8IVF Advice Coach
- Join Date
- Dec 2010
- Location
- The Internet
- Posts
- 24,567
- Post Thanks / Like
- Blog Entries
- 6
- Downloads
- 0
- Uploads
- 0
Mom to
and my IVF/PGD
It's better to look back on life and say: "I can't believe I did that" than to look back and say "I wish I did that".
New to IVF/PGD for Family Balancing? Read this- Understanding IVF/PGD- a HT Guide for those New to the IVF/PGD Process
Need a Natural Swaying Plan? Naturally sway for a boy or a girl- Personalized Swaying Plans
Become a Dream Member to access the private forums
-
May 1st, 2013, 01:05 AM #9Moderator
- Join Date
- Dec 2010
- Location
- Newport Beach, California
- Posts
- 441
- Post Thanks / Like
- Blog Entries
- 12
- Downloads
- 0
- Uploads
- 0
We will have a new test, GenderSure, available through Blastogen, starting in May. This test is done with a day 4 biopsy. aCGH is done as well as extra PCR specific to the sex chromosomes. The GenderSure test alleviates concerns regarding day 6 transfer and also provides 100% certainty for gender. I have been working with Barry Behr, PhD, Blastogen's scientific director on this test and we are very excited with our results so far. More details, ordering info and price to follow.
Daniel A. Potter, MD
Medical Director, HRC Fertility Newport Beach, California
Laboratory Director, Natera (formerly Gene Security Network)
http://www.amazon.com/What-When-You-...keywords=hanin
http://www.danielapottermd.com
@ivfgenderselect
-
May 1st, 2013, 01:09 AM #10
Thanks Dr Potter.
For those of us already pregnant with aCGH babies, can you please clarify the success of aCGH. There has been 95% quoted here as success, however I was thinking it was 99.9%.Australian couple
Parents to :4:2: Working with Dr Potter at HRC for our HT :or
Cycle #1 IVF in Australia (MIVF) 2010, ER 22, 18 fertilized, 6 survived to day 2, 1 TF = Chemical. 5 frozen day 2 - poor quality
Cycle #2 Aug 12 Dr Potter at HRC. ER 13, 10 mature, 9 fertilized, 8 to Day 3 PGD, 1 normal XX TF= BFN.
http://genderdreaming.com/forum/cycl...e-hrc-bfn.html
Sperm frozen at HRC so I can cycle alone next time
Cycle #3 December 12 Dr Potter HRC. Micro dose Lupron flare with GH. Preparation 12 weeks DHEA, acupuncture, chinese herbs, Metformin and extreme low carb diet. 11 eggs, 7 mature, 6 fertilized, 2 to day 5 Natera, both XY HB. NT :-(
http://genderdreaming.com/forum/cycl...ansfer-28.html
Cycle #4March 13 Dr Potter HRC. Micro dose lupron Flare with Follistim 450iu & Menopur 300iu & Saizen GH. Continued acupuncture, chinese herbs, low carb diet, Metformin and DHEA. Added fertility yoga. 31 Eggs, 24 Mature, 18 fertilized, 10 to day 5 aCGH, 4 normal Hatched Blasts- 3 XY and 1 XX. TF day 6 fully HB. 7dpd6t BFP.
Betas 7dpd6t = 134, 10dpd6t= 432, 12dpd6t = 713, 15dpd6t 2000
Ultrasound planned 15th April
Atomic, this may sound crazy but I’ve been reading about moon phases… I have a ‘red moon cycle’ currently which I didn’t used to have. Meaning my period is coinciding with the full moon. From...
Back again: blue sway planning